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France must end Ukraine’s 12-match unbeaten run and overturn a 2-0 first-leg deficit on Tuesday if they are to reach next year’s World Cup finals in Brazil.
Les Bleus conceded twice in the second half in Kiev on Friday night and then had Laurent Koscielny sent off in the final moments.
The Arsenal man’s place at centre-back is likely to be taken by Mamadou Sakho of Liverpool.
Striker Karim Benzema started on the bench in Kiev but manager Laurent Blanc could start both him and Olivier Giroud in Paris as they need goals.
Ukraine will reach their second ever World Cup if they hold on to their lead from the first leg. In 2006, they reached the quarter-finals in Germany.
Manager Mykhaylo Fomenko will be without centre-back Oleksandr Kucher after he picked up two bookings in added time on Friday night, with Yaroslav Rakitskiy likely to start in his place.